4-(4-(((2R,3R)-3-(3-Carbamimidoylbenzyl)-4-Methoxy-4-Oxobutan-2-Yl)Carbamoyl)Phenyl)Pyridine 1-Oxide Hydrochloride

Names

[ Name ]:
4-(4-(((2R,3R)-3-(3-Carbamimidoylbenzyl)-4-Methoxy-4-Oxobutan-2-Yl)Carbamoyl)Phenyl)Pyridine 1-Oxide Hydrochloride

[Synonym ]:
Methyl (2R,3R)-2-(3-amidinobenzyl)-3-((4-(1-oxido-4-pyridinyl)benzoyl)amino)butanoate hydrochloride
4-(4-((2R,3R)-3-(3-carbamimidoylbenzyl)-4-methoxy-4-oxobutan-2-ylcarbamoyl)phenyl)pyridine 1-oxide hydrochloride
Otamixaban hydrochloride [WHO-DD]
Otamixaban hydrochloride
UNII-WL9J31M2HI

Biological Activity

[Description]:

Otamixaban (FXV673) is a potent, selective, rapid-acting, competitive, and reversible fXa inhibitor (Ki=0.5 nM) that effectively inhibits both free and prothrombinase-bound fXa[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[Target]

IC50: Factor Xa[1]

[References]

[1]. Eikelboom JW, Weitz JI.Otamixaban in acute coronary syndromes.Lancet. 2009 Sep 5;374(9692):762-4. Epub 2009 Aug 28.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₇ClN₄O₄

[ Molecular Weight ]:
482.96

[ Exact Mass ]:
482.17200

[ PSA ]:
130.73000

[ LogP ]:
5.20930

Related Compounds

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