Uridine-d2-1

Names

[ CAS No. ]:
40632-21-1

[ Name ]:
Uridine-d2-1

[Synonym ]:
5,6-dideuterio-1-[(2R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Biological Activity

[Description]:

Uridine-d2-1 is the deuterium labeled Uridine[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Density]:
1.689g/cm3

[ Melting Point ]:
162-164ºC

[ Molecular Formula ]:
C9H10D2N2O6

[ Molecular Weight ]:
246.21400

[ Exact Mass ]:
246.08200

[ PSA ]:
124.78000

[ Index of Refraction ]:
1.643

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds