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7-Deaza-ddA

Names

[ CAS No. ]:
40627-30-3

[ Name ]:
7-Deaza-ddA

[Synonym ]:
7-Deaza-2',3'-dideoxyadenosine
((2S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydrofuran-2-yl)methanol
[(2S,5S)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-2-furanyl]methanol
2-Furanmethanol, 5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-, (2S,5S)-
[5-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-2-yl]-methanol
2-Furanmethanol, 5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-, (2S,5R)-
2',3'-dideoxytubercidin
[(2S,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-2-furanyl]methanol
ddTub

Biological Activity

[Description]:

7-Deaza-2',3'-dideoxyadenosine can be used in the synthesis of oligodeoxyribonucleotides[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Pauwels R, et, al. Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside. Biochem Pharmacol. 1988 Apr 1;37(7):1317-25.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
517.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H14N4O2

[ Molecular Weight ]:
234.255

[ Flash Point ]:
266.7±30.1 °C

[ Exact Mass ]:
234.111679

[ PSA ]:
86.19000

[ LogP ]:
-0.14

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.763

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds