DMeOB

Names

[ Name ]:
DMeOB

[Synonym ]:
3,3'-dimethoxybenzalazine
DMeOB
m-anisaldehyde azine
3,3'-dimethoxybenzaldazine
3-Methoxybenzaldehyde [(3-methoxyphenyl)methylene]hydrazone
3-methoxybenzaldehyde azine

Biological Activity

[Description]:

DMeOB is an agonist of mGluR5 receptor with an IC50 of 3 μM. DMeOB has a negative modulatory effect[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003 Sep;64(3):731-40.

Chemical & Physical Properties

[ Density]:
1.05g/cm3

[ Boiling Point ]:
438.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₆N₂O₂

[ Molecular Weight ]:
268.31

[ Flash Point ]:
176.1ºC

[ Exact Mass ]:
268.12100

[ PSA ]:
43.18000

[ LogP ]:
3.15680

[ Index of Refraction ]:
1.54

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318-H400

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;N: Dangerous for the environment;

[ Risk Phrases ]:
41-50/53

[ Safety Phrases ]:
26-36/37/39-60-61

[ RIDADR ]:
UN 3077 9/PG 3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

Mol. Pharmacol. 64 , 731-740, (2003)

We have identified a family of highly selective allosteric modulators of the group I metabotropic glutamate receptor subtype 5 (mGluR5). This family of closely related analogs exerts a spectrum of eff...