Tosyl phenylalanyl chloromethyl ketone
Names
[ CAS No. ]:
402-71-1
[ Name ]:
Tosyl phenylalanyl chloromethyl ketone
[Synonym ]:
(S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide
MFCD00000935
TPCK
Benzenesulfonamide, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl-
N-[(2S)-4-Chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide
Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-
N-(p-Toluenesulfonyl)-L-phenylalanyl Chloromethyl Ketone
L-1-4‘-Tosylamino-2-phenylethyl chloromethyl ketone
Tosyl phenylalanyl chloromethyl ketone
EINECS 206-954-6
N-[(2S)-4-Chloro-3-oxo-1-phenyl-2-butanyl]-4-methylbenzenesulfonamide
Tosyl-L-phenylalanyl-chloromethane
N-p-Tosyl-L-phenylalanine chloromethyl ketone
Benzenesulfonamide, N-((1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-
N-Tosyl-L-phenylalanyl Chloromethyl Ketone
L-1-4′-Tosylamino-2-phenylethyl chloromethyl ketone
N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK)
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
509.9±60.0 °C at 760 mmHg
[ Melting Point ]:
106-108ºC(lit.)
[ Molecular Formula ]:
C17H18ClNO3S
[ Molecular Weight ]:
351.848
[ Flash Point ]:
262.2±32.9 °C
[ Exact Mass ]:
351.069580
[ PSA ]:
71.62000
[ LogP ]:
3.98
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.583
[ Storage condition ]:
−20°C
[ Water Solubility ]:
DMSO: >10 mg/mL stable for several months at 4°C.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XT5613500
- CHEMICAL NAME :
- p-Toluenesulfonamide, N-(alpha-(chloroacetyl)phenethyl)-, (-)-
- CAS REGISTRY NUMBER :
- 402-71-1
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C17-H18-Cl-N-O3-S
- MOLECULAR WEIGHT :
- 351.87
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intrauterine
- DOSE :
- 160 mg/kg
- SEX/DURATION :
- female 2 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 25,954,1974
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H318-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R37/38
[ Safety Phrases ]:
26-36
[ RIDADR ]:
UN 3335
[ WGK Germany ]:
3
[ RTECS ]:
XT5613500
Articles
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Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic conc...
An immunoproteomic approach for characterization of dormancy within Staphylococcus epidermidis biofilms.Mol. Immunol. 65(2) , 429-35, (2015)
Virulence of Staphylococcus epidermidis is mainly attributed to surface colonization and biofilm formation in indwelling medical devices. Physiological heterogeneity of biofilms may influence host imm...
Proteomic profile of dormancy within Staphylococcus epidermidis biofilms using iTRAQ and label-free strategies.Appl. Microbiol. Biotechnol. 99(6) , 2751-62, (2015)
Staphylococcus epidermidis is an important nosocomial bacterium among carriers of indwelling medical devices, since it has a strong ability to form biofilms. The presence of dormant bacteria within a ...