Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 trifluoroacetate salt

Names

[ CAS No. ]:
400716-78-1

[ Name ]:
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 trifluoroacetate salt

[Synonym ]:
L-α-Glutamine, N-acetyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6- [4-[(E)-2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-L-lysyl-
N-Acetyl-L-α-glutamyl-N-{2-[(5-sulfo-1-naphthyl)amino]ethyl}-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6-(4-{(E)-[4-(dimethylami no)phenyl]diazenyl}benzoyl)-L-lysyl-L-α-glutamine

Biological Activity

[Description]:

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

Cathepsin D


[References]

[1]. Eketjäll S, et al. AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. J Alzheimers Dis. 2016;50(4):1109-23.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C104H146N24O23S

[ Molecular Weight ]:
2132.484

[ Exact Mass ]:
2131.071289

[ LogP ]:
4.90

[ Index of Refraction ]:
1.647