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4-Hydroperoxy cyclophosphamide

Names

[ CAS No. ]:
39800-16-3

[ Name ]:
4-Hydroperoxy cyclophosphamide

[Synonym ]:
PERFOSFAMIDE
ASTA 6496
4-Hydroperoxycyclofosfamide
4-Hydroperoxycyclophosphamide
4-OOH Cyclophosphamide
N,N-bis(2-chloroethyl)-4-hydroperoxy-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-2-amine
Perfosphamide
4-Hydroperoxy-cyclophosphamid

Biological Activity

[Description]:

4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide is used to treat lymphomas and autoimmune disorders.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

Chemical & Physical Properties

[ Density]:
1.465g/cm3

[ Boiling Point ]:
419.946ºC at 760 mmHg

[ Melting Point ]:
100-103ºC

[ Molecular Formula ]:
C7H15Cl2N2O4P

[ Molecular Weight ]:
293.08500

[ Flash Point ]:
207.776ºC

[ Exact Mass ]:
292.01500

[ PSA ]:
80.84000

[ LogP ]:
2.02850

[ Index of Refraction ]:
1.525

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP5900000
CHEMICAL NAME :
2H-1,3,2-Oxazophosphorine, 2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-, 2-oxide
CAS REGISTRY NUMBER :
39800-16-3
LAST UPDATED :
199612
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C7-H15-Cl2-N2-O4-P
MOLECULAR WEIGHT :
293.11
WISWESSER LINE NOTATION :
T6MPOTJ BN2G2G FOQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
76040 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
5 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,1163,1986

Related Compounds

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