Methyl 3,4-dihydroxy-5-methoxybenzoate

Names

[ Name ]:
Methyl 3,4-dihydroxy-5-methoxybenzoate

[Synonym ]:
3,4-Dihydroxy-5-methoxybenzoic acid methyl ester
Methyl-O-methylgallate
Methyl 3-O-methyl gallate
Benzoic acid, 3,4-dihydroxy-5-methoxy-, methyl ester
Methyl 3,4-dihydroxy-5-methoxybenzoate
M3OMG
3,4-Dihydroxy-5-methoxy-benzoic acid methyl ester
methyl 4,5-dihydroxy-3-methoxybenzoate
methyl 3-methoxy-4,5-dihydroxybenzoate
methyl 5-methoxy-3,4-dihydroxybenzoate
Benzoic acid,3,4-dihydroxy-5-methoxy-,methyl ester

Biological Activity

[Description]:

Methyl 3-O-methylgallate (M3OMG) possesses antioxidant effect and can protect neuronal cells from oxidative damage[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

Methyl 3-O-methylgallate (M3OMG; 10 and 20 mg/kg, i.p., ) treatment mitigated the NaF-induced oxidative stress through normalization of the level of TBARS, reduced levels of glutathione and by the restoration of the diminished antioxidant enzyme activities[1]. Animal Model: Fifty male Wistar rats (8-12 , 7-days old, 200-250 g)[1]. Dosage: 10 and 20 mg/kg. Administration: I.P. for 1 week. Result: Mitigated the NaF-induced oxidative stress through normalization of the level of TBARS, reduced levels of glutathione and by the restoration of the diminished antioxidant enzyme activities.

[References]

[1]. Nabavi SF, et al. Neuroprotective effects of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in the brain of rats. Cell Mol Neurobiol. 2013 Mar;33(2):261-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
391.7±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₀O₅

[ Molecular Weight ]:
198.17

[ Flash Point ]:
160.5±20.0 °C

[ Exact Mass ]:
198.052826

[ PSA ]:
75.99000

[ LogP ]:
1.49

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.568

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%