[(pF)Phe4]Nociceptin(1-13)NH2
Names
[ CAS No. ]:
380620-88-2
[ Name ]:
[(pF)Phe4]Nociceptin(1-13)NH2
[Synonym ]:
phe-gly-gly-pfluorophe-thr-gly-ala-arg-lys-ser-ala-arg-lys-nh2
m.w. 1399.60 c61h99fn22o15
Biological Activity
[Description]:
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP (OP4) agonists, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold)[1][2].
[Related Catalog]:
[In Vivo]
In unanaesthetised normotensive mice, bolus intravenous injection of 100 nmol/kg of [(pF)Phe4]Nociceptin(1-13)NH2 decreases mean blood pressure and heart rate; these effects are longer lasting than those elicited by the same dose of NC(1-13)NH2. I.c.v. administration of [(pF)Phe4]Nociceptin(1-13)NH2 dose-dependently stimulated feeding in rats, and is about tenfold more potent than NC(1-13)NH2[2].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C61H99FN22O15
[ Molecular Weight ]:
1471.54000
[ Exact Mass ]:
1470.73000
[ PSA ]:
634.61000
[ LogP ]:
1.76300