SRPIN-803

Names

[ Name ]:
SRPIN-803

[Synonym ]:
(6E)-6-(4-Hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
7H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-7-one, 5,6-dihydro-6-[(4-hydroxy-3-methoxyphenyl)methylene]-5-imino-2-(trifluoromethyl)-, (6E)-

Biological Activity

[Description]:

SRPIN-803 (SRPIN 803, SRPIN803) is a novel small molecule dual inhibitor of SRPK1 and CK2 with IC50 of 2.4 uM and 0.2 uM, respectively, does not inhibit SRPK2; prevents VEGF production more effectively than SRPIN340, topical administration of SRPIN803 suppresses intraocular neovascularization in mouse model.

[References]

References 1. Morooka S, et al. Mol Pharmacol. 2015 Aug;88(2):316-25. View Related Products by Target SRPK

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
428.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₉F₃N₄O₃S

[ Molecular Weight ]:
370.306

[ Flash Point ]:
212.9±31.5 °C

[ Exact Mass ]:
370.034760

[ LogP ]:
1.60

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.678

Related Compounds

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