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Semapimod

Names

[ CAS No. ]:
352513-83-8

[ Name ]:
Semapimod

[Synonym ]:
AXD455
UNII-9SGW2H1K8P
Semapimod
CNI-1493

Biological Activity

[Description]:

Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology

[Target]

CD40

IL-1β

IL-6

p38 MAPK


[References]

[1]. Nishimatsu H, et al. Blockade of endogenous proinflammatory cytokines ameliorates endothelial dysfunction in obese Zucker rats. Hypertens Res. 2008;31(4):737‐743.  

[2]. Wehner S, Set al. Inhibition of p38 mitogen-activated protein kinase pathway as prophylaxis of postoperative ileus in mice. Gastroenterology. 2009;136(2):619‐629.  

[3]. Wang J, et al. Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96. J Immunol. 2016;196(12):5130‐5137.  

[4]. Miller IS, et al. Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia. PLoS One. 2014 May 9;9(5):e95885.  

Chemical & Physical Properties

[ Density]:
1.39

[ Molecular Formula ]:
C34H52N18O2

[ Molecular Weight ]:
744.90

[ Exact Mass ]:
744.45200

[ PSA ]:
355.24000

[ LogP ]:
7.12260

[ Index of Refraction ]:
1.677

Related Compounds