17β-Estradiol sulfate-d4 sodium

Names

[ CAS No. ]:
352431-50-6

[ Name ]:
17β-Estradiol sulfate-d4 sodium

[Synonym ]:
Estra-1,3,5(10)-triene-2,4,16,16-d-3,17-diol, 3-(hydrogen sulfate), sodium salt, (17β)- (1:1)
Sodium (17β)-17-hydroxy(2,4,16,16-H)estra-1,3,5(10)-trien-3-yl sulfate

Biological Activity

[Description]:

17β-Estradiol sulfate-d4 (sodium) is the deuterium labeled 17β-Estradiol sulfate 17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Li W, et al. Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther. 2007;323(1):236-247.

[3]. Schneider C, et al. A novel enzyme-linked immunosorbent assay for ethynylestradiol using a long-chain biotinylated EE2 derivative. Steroids. 2004;69(4):245-253.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19D4NaO5S

[ Molecular Weight ]:
378.45

[ Exact Mass ]:
378.141510

[ PSA ]:
95.04000

[ LogP ]:
3.82340

Related Compounds