IRES-C11

Names

[ Name ]:
IRES-C11

[Synonym ]:
1H-Pyrrole-2,5-dione, 3,4-dichloro-1-[(2,4-dimethoxyphenyl)methyl]-
3,4-Dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione

Biological Activity

[Description]:

A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells; shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation; significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib; shows synergistic anti-MM cytotoxicity combined with ER stress inducers; also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242.

[References]

References 1. Shi Y, et al. Oncogene. 2016 Feb 25;35(8):1015-24. 2. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
415.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₁Cl₂NO₄

[ Molecular Weight ]:
316.137

[ Flash Point ]:
205.3±28.7 °C

[ Exact Mass ]:
315.006500

[ LogP ]:
2.16

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.605

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.