3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE

Names

[ CAS No. ]:
341944-06-7

[ Name ]:
3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE

[Synonym ]:
1H-1,2,4-Triazol-5-amine, 3-[[(2-chlorophenyl)methyl]thio]-
MFCD00215049
3-[(2-Chlorobenzyl)sulfanyl]-1H-1,2,4-triazol-5-amine
4H-1,2,4-triazol-3-amine, 5-[[(2-chlorophenyl)methyl]thio]-
5-[(2-Chlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
MFCD03847132

Biological Activity

[Description]:

Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 15 μM (RpMetAP1)[1]

[In Vitro]

Antibacterial agent 117 can inhibit RpMetAP1 with an IC50 value of 15 μM[1]. Antibacterial agent 117 (0.3 μM, 3 μM, 30 μM and 300 μM) stimulates endothelial cell (EC) metabolism and also inhibits rickettsial growth[1].

[References]

[1]. Travis R Helgren, et al. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
488.6±47.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₉ClN₄S

[ Molecular Weight ]:
240.713

[ Flash Point ]:
249.3±29.3 °C

[ Exact Mass ]:
240.023651

[ LogP ]:
2.41

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
2-8°C