Pachypodol

Names

[ Name ]:
Pachypodol

[Synonym ]:
5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one
5,4'-dihydroxy-3,3',7-trimethoxyflavone
quercetin 3,3',7-trimethyl ether
4',5-Dihydroxy-3,3',7-trimethoxyflavone
Pachypodol
5,4'-dihydroxy-3,7,3'-trimethoxyflavone
Quercetin 3,7,3'-trimethyl ether
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-
5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxychromen-4-one

Biological Activity

[Description]:

Pachypodol exerts antioxidant and cytoprotective effects in HepG2 cells[1].Pachypodol inhibits the growth of CaCo 2 colon cancer cell line in vitro(IC50 = 185.6 mM)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Kim EK, et al. Pachypodol, a Methoxyflavonoid Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation. Int J Mol Sci. 2019;20(17):4082. Published 2019 Aug 21.

[2]. Ali HA,et al. Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro. Phytother Res. 2008;22(12):1684-1687.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
598.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₆O₇

[ Molecular Weight ]:
344.32

[ Flash Point ]:
220.7±23.6 °C

[ Exact Mass ]:
344.089600

[ PSA ]:
98.36000

[ LogP ]:
2.56

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.654

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%