8H-13,3,6a-Ethanylylidene-7,10-methanooxepino[3,4-i]-1-benzazocin-8-one,1-ethyltetradecahydro-12a,14-dihydroxy-6-methoxy-3-methyl-,(3R,6S,6aS,7R,7aS,10S,12aS,13R,13aR,14S,15R)-

Names

[ Name ]:
8H-13,3,6a-Ethanylylidene-7,10-methanooxepino[3,4-i]-1-benzazocin-8-one,1-ethyltetradecahydro-12a,14-dihydroxy-6-methoxy-3-methyl-,(3R,6S,6aS,7R,7aS,10S,12aS,13R,13aR,14S,15R)-

[Synonym ]:
7-Ethyl-10-methoxy-20-deoxyaminocamptothecin
20-deoxyamino-7-ethyl-10-methoxycamptothecin

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Boiling Point ]:
583.2ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₃₃NO₅

[ Molecular Weight ]:
391.50100

[ Flash Point ]:
306.5ºC

[ Exact Mass ]:
391.23600

[ PSA ]:
79.23000

[ LogP ]:
1.12320

[ Index of Refraction ]:
1.612

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MK6800000

CHEMICAL NAME :: Heteratisan-14-one, 6,8-dihydroxy-20-ethyl-1-methoxy-4-methyl-, (1-alpha,6-beta)-

CAS REGISTRY NUMBER :: 3328-84-5

BEILSTEIN REFERENCE NO. :: 0052343

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H33-N-O5

MOLECULAR WEIGHT :: 391.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 254 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,180,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,180,1984

Precursor & DownStream

Precursor

DownStream

Related Compounds

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