Humanin (human) trifluoroacetate salt

Names

[ Name ]:
Humanin (human) trifluoroacetate salt

[Synonym ]:
1-24-Protein humanin (human)
Protein (human clone 1 humanin sequence homolog)
MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA
MAPRGFSCLLLLTSEIDLPVKRRA

Biological Activity

[Description]:

Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Endocrinology

Research Areas >> Neurological Disease

[Target]

Bax

[In Vitro]

Humanin (40 nM，罗丹明偶联；30 min) 抑制野生型 HCT116 细胞受 Bax 蛋白诱导的细胞死亡[1]。 Humanin (100 μM；10 min) 阻断 Bax 与分离线粒体的关联，并抑制野生型 HCT116 细胞中细胞色素 c 的释放[1]。 Humanin 减少 0.2 mM STS 诱导的细胞半凋亡[1]。 Humanin 不能抑制 Bax 缺陷的 HCT116 细胞的凋亡[1]。

[In Vivo]

Humanin (0.375 mg/kg/hr; 静脉注射) 增加 Zucker 糖尿病脂肪 (ZDF) 大鼠对外周胰岛素敏感性[2]。

[References]

[1]. Guo B, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003 May 22;423(6938):456-61.

[2]. Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22;4(7):e6334.

Chemical & Physical Properties

[ Density]:
1.43±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C₁₁₉H₂₀₄N₃₄O₃₂S₂

[ Molecular Weight ]:
2687.23000

[ Exact Mass ]:
2685.48000

[ PSA ]:
1126.15000

[ LogP ]:
4.77230

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn

Humanin (human) trifluoroacetate salt

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds