N-piperidine Ibrutinib

Names

[ Name ]:
N-piperidine Ibrutinib

Biological Activity

[Description]:

BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk). BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[References]

[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₂N₆O

[ Molecular Weight ]:
386.45

[ Storage condition ]:
-20℃

Related Compounds

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