Benzylamine hydrochloride

Names

[ Name ]:
Benzylamine hydrochloride

[Synonym ]:
benzyl amine hydrochloride
Phenylmethanamine hydrochloride
Phenylmethylamine
PhCH2NH2 hydrochloride
BENZYLAMINE HCl
BnNH2 hydrochloride
EINECS 221-943-6
Benzenemethanamine, hydrochloride (1:1)
benzylammonium chloride
1-Phenylmethanamine hydrochloride (1:1)
Benzylamine Hydrochloride
MFCD00012852
Lacosamide Impurity 10

Chemical & Physical Properties

[ Boiling Point ]:
185ºC at 760 mmHg

[ Melting Point ]:
262-263 °C(lit.)

[ Molecular Formula ]:
C₇H₁₀ClN

[ Molecular Weight ]:
143.614

[ Flash Point ]:
60ºC

[ Exact Mass ]:
143.050171

[ PSA ]:
26.02000

[ LogP ]:
2.64760

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DP5425000

CHEMICAL NAME :: Benzylamine, hydrochloride

CAS REGISTRY NUMBER :: 3287-99-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H9-N.Cl-H

MOLECULAR WEIGHT :: 143.63

WISWESSER LINE NOTATION :: Z1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 9,390,1951 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82149 No. of Facilities: 314 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 3082 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DP5425000

[ HS Code ]:
29214980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Investigation of the sunscreen octocrylene's interaction with amino acid analogs in the presence of UV radiation.

Photochem. Photobiol. 88(4) , 904-12, (2012)

Octocrylene is an organic UV filter, commonly used in sunscreens and cosmetics, which can give rise to both contact and photocontact allergy. Our aim was to investigate octocrylene's interaction with ...

Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter.

J. Physiol. Biochem. 68(4) , 651-62, (2012)

Semicarbazide-sensitive amine oxidase (SSAO) is a transmembrane enzyme that metabolizes primary amines from endogenous or dietary origin. SSAO is highly expressed in adipose, smooth muscle and endothe...

Functional modulation of vascular adhesion protein-1 by a novel splice variant.

PLoS ONE 8(1) , e54151, (2013)

Vascular Adhesion Protein-1 (VAP-1) is an endothelial adhesion molecule belonging to the primary amine oxidases. Upon inflammation it takes part in the leukocyte extravasation cascade facilitating tra...