R-(+)-Cotinine

Names

[ Name ]:
R-(+)-Cotinine

[Synonym ]:
COTININE (+)-
R-(+)-Cotinine
R-(+)-COTININE ((5R)-(+)-1-METHYL-5-(3-PYRIDIYL)-2-PYRROLIDINONE)

Biological Activity

[Description]:

R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

R-(+)-Cotinine (1 μM) significantly enhances the Ach (40 μM)-evoked current in human α7 nAChRs[1].

[In Vivo]

R-(+)-Cotinine (0.3-10 mg/kg; a single i.p.) enhances the effects of a subthreshold dose of Donepezil (0.5 mg/kg) on novel object recognition (NOR) performance[1].

[References]

[1]. Jr AVT, et, al. R-(+) and S-(-) isomers of cotinine augment cholinergic responses in vitro and in vivo. J Pharmacol Exp Ther. 2015 Feb;352(2):405-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₂N₂O

[ Molecular Weight ]:
176.22

[ Exact Mass ]:
176.09500

[ PSA ]:
33.20000

[ LogP ]:
1.31280

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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