3,5-Dichloro-2-hydroxybenzoic acid

Names

[ CAS No. ]:
320-72-9

[ Name ]:
3,5-Dichloro-2-hydroxybenzoic acid

[Synonym ]:
3,5-Cl2salH
3,5-Dichlorosalicylic acid
Salicylic acid,3,5-dichloro
Benzoic acid,3,5-dichloro-2-hydroxy
USAF DO-68
Benzoic acid, 3,5-dichloro-2-hydroxy-
EINECS 206-281-8
2-Hydroxy-3,5-dichlorobenzoic acid
3,5-dichloro-2-hydroxy-benzoic acid
3,5-Dichloro-2-hydroxybenzoic acid
MFCD00002442

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
319.3±42.0 °C at 760 mmHg

[ Melting Point ]:
221-224 °C

[ Molecular Formula ]:
C₇H₄Cl₂O₃

[ Molecular Weight ]:
207.011

[ Flash Point ]:
146.9±27.9 °C

[ Exact Mass ]:
205.953751

[ PSA ]:
57.53000

[ LogP ]:
4.40

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.641

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO2450000

CHEMICAL NAME :: Salicylic acid, 3,5-dichloro-

CAS REGISTRY NUMBER :: 320-72-9

BEILSTEIN REFERENCE NO. :: 2210803

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H4-Cl2-O3

MOLECULAR WEIGHT :: 207.01

WISWESSER LINE NOTATION :: QVR BQ CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VO2450000

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Spectral deciphering of the interaction between an intramolecular hydrogen bonded ESIPT drug, 3,5-dichlorosalicylic acid, and a model transport protein.

Phys. Chem. Chem. Phys. 14(25) , 8892-902, (2012)

The present work demonstrates a detailed characterization of the interaction of a bio-active drug molecule 3,5-dichlorosalicyclic acid (3,5DCSA) with a model transport protein Bovine Serum Albumin (BS...

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.

Arch. Biochem. Biophys. 479(1) , 82-7, (2008)

The structure of aldehyde reductase (ALR1) in ternary complex with the coenzyme NADPH and 3,5-dichlorosalicylic acid (DCL), a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1), w...