Neuropeptide VF (124-131) (human) trifluoroacetate salt

Names

[ Name ]:
Neuropeptide VF (124-131) (human) trifluoroacetate salt

[Synonym ]:
RFRP-3 human trifluoroacetate salt
H2N-VPNLPQRF-AMIDE
V-8-F-NH2,NPVF
NPVF
V-8-F-NH2
Neuropeptide VF (124-131) (human)

Biological Activity

[Description]:

RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[In Vitro]

RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1]. Scatchard-plot analysis shows that 125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kd value and the Bmax values are 0.19 nM and 1.3 pM, respectively. RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1]. RFRP-3 (10-8 to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination[1].

[References]

[1]. Iain J Clarke, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology

[2]. Iain J Clarke, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₅H₇₂N₁₄O₁₀

[ Molecular Weight ]:
969.14100

[ Exact Mass ]:
968.55600

[ PSA ]:
403.31000

[ LogP ]:
2.37640

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.