Cyclopamine-KAAD

Names

[ Name ]:
Cyclopamine-KAAD

[Synonym ]:
Cyclopamine-KAAD
Shh Signaling Antagonist II
3-Keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl Cyclopamine
KAAD-Cyclopamine

Biological Activity

[Description]:

KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo

Research Areas >> Cancer

[In Vitro]

KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC50 of 3 nM, wheras this cyclopamine derivative has an IC50 of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine[1].

[References]

[1]. Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2(1):29-30.

[2]. Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26(10):1698-705.

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
875.6ºC at 760 mmHg

[ Molecular Formula ]:
C₄₄H₆₃N₃O₄

[ Molecular Weight ]:
697.99

[ Flash Point ]:
483.3ºC

[ Exact Mass ]:
697.48200

[ PSA ]:
101.73000

[ LogP ]:
8.40240

[ Index of Refraction ]:
1.588

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.