3-Amino-4-phenylbutyric acid hydrochloride

Names

[ Name ]:
3-Amino-4-phenylbutyric acid hydrochloride

[Synonym ]:
4-Amino-3-phenylbutanoic acid hydrochloride
PHENIBUT
4-Amino-3-phenyl-buttersaeure,Hydrochlorid
3-AMINO-4-PHENYLBUTYRIC ACID HCL
MFCD00456233
3-Amino-4-phenylbutanoic acid hydrochloride (1:1)
FENIBUT
4-amino-3-phenyl-butyric acid,hydrochloride
Benzenebutanoic acid, β-amino-, hydrochloride (1:1)
4-AMINO-3-PHENYL-BUTYRIC ACID
4-AMINO-3-PHENYLBUTIRIC ACID
Phenibut(4-Amino-3-Phenylbutanoic Acid HCl)

Biological Activity

[Description]:

Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist[1]. Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

GABA-B[1][2]

[In Vitro]

Phenibut hydrochloride is a neuropsychotropic agent. Phenibut hydrochloride also stimulates dopamine receptors and antagonizes β-phenethylamine (PEA), a putative endogenous anxiogenic[2].

[References]

[1]. Ahuja T, et al. Phenibut (β-Phenyl-γ-aminobutyric Acid) Dependence and Management of Withdrawal: EmergingNootropics of Abuse. Case Rep Psychiatry. 2018 Apr 30;2018:9864285.

[2]. Lapin I. Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Rev. 2001 Winter;7(4):471-81.

Chemical & Physical Properties

[ Density]:
1.161g/cm3

[ Boiling Point ]:
327.8ºC at 760 mmHg

[ Melting Point ]:
194-201ºC

[ Molecular Formula ]:
C₁₀H₁₄ClNO₂

[ Molecular Weight ]:
215.677

[ Flash Point ]:
152.1ºC

[ Exact Mass ]:
215.071304

[ PSA ]:
63.32000

[ LogP ]:
2.53340

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%