Dodecyl octaethylene glycol ether

Names

[ Name ]:
Dodecyl octaethylene glycol ether

[Synonym ]:
MFCD00043234
3,6,9,12,15,18,21,24-Octaoxahexatriacontan-1-ol
Dodecyloctaglycol
Polyoxyethylene (8) lauryl ether
Octaethylene Glycol Monododecyl Ether
octaoxyethylene glycol mono-n-dodecyl ether
n-dodecyl octaethylene glycol monoether
O-DODECANYL OCTAETHYLENE GLYCOL
octaethyleneglycol dodecyl ether
Dodecyl octaethylene glycol ether
2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
EINECS 231-791-2
octakis(ethylene glycol) mono-n-dodecyl ether
C12E8,Dodecyl octaethylene glycol ether,Dodecyloctaglycol
Octaethyleneglycol-dodecylmonoether
n-dodecyloctaoxyethylene glycol monoether
dodecyloctaethyleneglycol monoether
C12E8 Dodecyl octaethylene glycol ether Dodecyloctaglycol Polyoxyethylene (8) lauryl ether

Biological Activity

[Description]:

Octaethylene glycol monododecyl ether (C12E8) is an non-ionic detergent that can be used for membrane protein extraction. Octaethylene glycol monododecyl ether can solubilize the viral membrane of intact influenza virus[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[In Vitro]

Octaethylene glycol monododecyl ether (C12E8) has been shown to solubilize the viral membrane of intact influenza virus. The mechanism of solubilization of the viral membrane is based on the accumulation of C12E8 molecules outside the membrane until the formation of micelles leading to the extraction of membrane constituents[1].

[References]

[1]. Véronique Nardello-Rataj, et al. Aqueous solutions of didecyldimethylammonium chloride and octaethylene glycol monododecyl ether: Toward synergistic formulations against enveloped viruses. Int J Pharm. 2016 Sep 10;511(1):550-559.

[2]. C Carnero Ruiz, et al. Characterization of mixed non-ionic surfactants n-octyl-β-D-thioglucoside and octaethylene-glycol monododecyl ether: micellization and microstructure. J Colloid Interface Sci. 2011 Sep 1;361(1):178-85.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
585.5±45.0 °C at 760 mmHg

[ Melting Point ]:
30ºC

[ Molecular Formula ]:
C₂₈H₅₈O₉

[ Molecular Weight ]:
538.755

[ Flash Point ]:
307.9±28.7 °C

[ Exact Mass ]:
538.408081

[ PSA ]:
94.07000

[ LogP ]:
2.54

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.459

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Folding and Intramembraneous BRICHOS Binding of the Prosurfactant Protein C Transmembrane Segment.

J. Biol. Chem. 290 , 17628-41, (2015)

Surfactant protein C (SP-C) is a novel amyloid protein found in the lung tissue of patients suffering from interstitial lung disease (ILD) due to mutations in the gene of the precursor protein pro-SP-...

Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3)

Chem. Biol. Interact. 234 , 178-87, (2015)

• DHRS3 is an integral membrane protein with its C-terminus in the cytosol. • Androstenedione and estrone are substrates of DHRS3 in vitro. • DHRS3 was inserted into proteoliposomes. • Expression of D...

Octadecyl ferulate behavior in 1,2-Dioleoylphosphocholine liposomes.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 153 , 333-43, (2015)

Octadecyl ferulate was prepared using solid acid catalyst, monitored using Supercritical Fluid Chromatography and purified to a 42% yield. Differential scanning calorimetry measurements determined oct...