Biotin-PEG2-Mal

Names

[ Name ]:
Biotin-PEG2-Mal

[Synonym ]:
N-Biotinyl-N'-(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[2-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-
B3174
N-{2-[2-(2-{[3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]amino}ethoxy)ethoxy]ethyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Maleimide-PEG2-Biotin

Biological Activity

[Description]:

Biotin-PEG2-Mal is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
897.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₅N₅O₇S

[ Molecular Weight ]:
525.618

[ Flash Point ]:
496.3±34.3 °C

[ Exact Mass ]:
525.225708

[ PSA ]:
190.94000

[ LogP ]:
-1.76

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.550

[ Storage condition ]:
-20 ℃

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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