OB-1

Names

[ Name ]:
OB-1

[Synonym ]:
MFCD01462999
3-Benzofurancarboxylic acid, 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-, ethyl ester
Ethyl 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-1-benzofuran-3-carboxylate

Biological Activity

[Description]:

A small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo; also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity.

[References]

References 1. Wetzel C, et al. Nat Neurosci. 2017 Feb;20(2):209-218. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
628.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₇N₃O₆

[ Molecular Weight ]:
407.376

[ Flash Point ]:
333.9±31.5 °C

[ Exact Mass ]:
407.111725

[ LogP ]:
5.15

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.649

Related Compounds

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