N-Desmethyl Clomipramine Hydrochloride
Names
[ CAS No. ]:
29854-14-6
[ Name ]:
N-Desmethyl Clomipramine Hydrochloride
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Boiling Point ]:
466ºC at 760 mmHg
[ Melting Point ]:
204-206°C (dec.)
[ Molecular Formula ]:
C18H22Cl2N2
[ Molecular Weight ]:
337.28700
[ Flash Point ]:
235.6ºC
[ Exact Mass ]:
336.11600
[ PSA ]:
15.27000
[ LogP ]:
5.44410
[ Vapour Pressure ]:
4.41E-09mmHg at 25°C
[ Storage condition ]:
-20°C Freezer
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311 + H331-H370
[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311
[ Hazard Codes ]:
F,T
[ Risk Phrases ]:
11-23/24/25-39/23/24/25
[ Safety Phrases ]:
7-16-36/37-45
[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution
Articles
Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000)
Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami...
Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.J. Affect. Disord. 29(4) , 267-79, (1993)
We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D...
Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.Am. J. Vet. Res. 61(1) , 80-5, (2000)
To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages....