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Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt

Names

[ CAS No. ]:
292633-16-0

[ Name ]:
Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt

[Synonym ]:
N-Acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine
ac-lehd-amc trifluoroacetate salt
L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
ac-lehd-amc
ac-lehd-mca
n-acetyl-leu-glu-his-asp-7-amino-4-methylcoumarin amc
ac-leu-glu-his-asp-mca
ac-leu-glu-his-asp-7-amino-4-methylcoumarin

Biological Activity

[Description]:

Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Apoptosis >> Caspase

[References]

[1]. Igor M Prudnikov, et al. Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases. J Biochem. 2012 Mar;151(3):299-316.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1258.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C33H41N7O11

[ Molecular Weight ]:
711.719

[ Flash Point ]:
714.6±34.3 °C

[ Exact Mass ]:
711.286377

[ PSA ]:
278.99000

[ LogP ]:
0.94

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.605

Related Compounds