Anticancer agent 99

Names

[ CAS No. ]:
2914922-83-9

[ Name ]:
Anticancer agent 99

Biological Activity

[Description]:

Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Anticancer agent 99 (0-50 μM, 24 h)可直接上调 Bax 表达并诱导 HepG2 细胞系中的 caspase-3 依赖性细胞凋亡，具有抗增殖作用[1]。 Apoptosis Analysis[1] Cell Line: HepG2 cell Concentration: 25, 50 μM Incubation Time: 24 h Result: Increased mRNA transcript levels of pro-apoptotic Bax and Caspase-3 genes. Reduced Akt protein levels in HepG2 cells. Increased FoXO1, TXNIP and p27 protein levels in HepG2 cells.

[References]

[1]. M İhsan Han, et al. Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones. ACS Omega. 2023 Feb 28;8(10):9198-9211.   

Chemical & Physical Properties

[ Molecular Formula ]:
C19H20F3N3O2

[ Molecular Weight ]:
379.38

Related Compounds