Fesoterodine Fumarate

Names

[ Name ]:
Fesoterodine Fumarate

[Synonym ]:
(R)-Fesoterodine fumarate
Fesoterodine Fumarate
UNII-EOS72165S7
SPM 8272
SPM 907
Propanoic acid, 2-methyl-, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1)
Toviaz,Fesoterodine fumarate
2-[(1R)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1)
Propanoic acid,2-methyl-,2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl ester,(2E)-2-butenedioate (1:1) (salt)
Fesoterodinefumarate
Toviaz
(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl isobutyrate fumarate
Fesoterodine (fumarate)

Biological Activity

[Description]:

Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.IC50 value:Target: mAChRFesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists. Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. Staskin David; Khullar Vik; Michel Martin C et al. Effects of voluntary dose escalation in a placebo-controlled, flexible-dose trial of fesoterodine in subjects with overactive bladder. Neurourology and urodynamics (2011), 30(8), 1480-5.

[2]. Vella Maria; Cardozo Linda Review of fesoterodine. Expert opinion on drug safety (2011), 10(5), 805-8.

[3]. Malhotra Bimal; Alvey Christine; Gong Jason et al. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. British journal of clinical pharmacology (2011), 72(2), 257-62.

[4]. Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert Opin Pharmacother. 2008 Jul;9(10):1787-96.

[5]. Fesoterodine

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
518.9ºC at 760 mmHg

[ Melting Point ]:
72-78ºC

[ Molecular Formula ]:
C₃₀H₄₁NO₇

[ Molecular Weight ]:
527.649

[ Flash Point ]:
267.6ºC

[ Exact Mass ]:
527.288330

[ PSA ]:
124.37000

[ LogP ]:
5.09290

[ Storage condition ]:
Hygroscopic, Store under Inert atmosphere -20°C Freezer

Related Compounds

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