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Euphorbiasteroid

Names

[ CAS No. ]:
28649-59-4

[ Name ]:
Euphorbiasteroid

[Synonym ]:
Epoxylathyrol
euphorbiasteroid
Benzeneacetic acid, (1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
Benzeneacetic acid, (1aR,2E,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
6,20-Epoxylathyrol-5,10-diacetat-3-phenylacetat
(1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
(1aR,2E,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
1,10-epoxyaristolane

Biological Activity

[Description]:

Euphorbiasteroid is a tricyclic diperpene of Euphorbia lathyris L., inhibits tyrosinase, and increases the phosphorylation of AMPK, with anti-cancer, anti-virus, anti-obesity and multidrug resistance-modulating effect[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Research Areas >> Metabolic Disease

[References]

[1]. Park SJ, et al. Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells via activation of AMP-activated protein kinase. Cell Biochem Funct. 2015 Jun;33(4):220-5.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
633.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H40O8

[ Molecular Weight ]:
552.655

[ Flash Point ]:
263.9±31.5 °C

[ Exact Mass ]:
552.272339

[ PSA ]:
108.50000

[ LogP ]:
5.55

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.566

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
29061990

Related Compounds

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