6-Ethoxydihydrosanguinarine

Names

[ Name ]:
6-Ethoxydihydrosanguinarine

[Synonym ]:
[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine, 14-ethoxy-13,14-dihydro-13-methyl-
6-ethoxydihydrosanguinarine
Sanguinarin
ethoxysanguinarine
O-ethyl-sanguinarine
14-Ethoxy-13-methyl-13,14-dihydro[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridine

Biological Activity

[Description]:

Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting protein phosphatase 2A (CIP2A)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Jin L, et al. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting CIP2A. Int J Oncol. 2018 Mar 16.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
563.7±50.0 °C at 760 mmHg

[ Melting Point ]:
210-212℃(ethanol)

[ Molecular Formula ]:
C₂₂H₁₉NO₅

[ Molecular Weight ]:
377.390

[ Flash Point ]:
169.0±27.3 °C

[ Exact Mass ]:
377.126312

[ PSA ]:
50.03000

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.724

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%