Futoquinol

Names

[ Name ]:
Futoquinol

[Synonym ]:
2-Allyl-4-[(1E)-1-(1,3-benzodioxol-5-yl)-1-propen-2-yl]-4,5-dimethoxy-2,5-cyclohexadien-1-one
2-Allyl-4-[(E)-2-(1,3-benzodioxol-5-yl)-1-methylethenyl]-4,5-dimethoxy-2,5-cyclohexadien-1-one
(E)-2-Allyl-4-(2-(1,3-benzodioxol-5-yl)-1-methylvinyl)-4,5-dimethoxy-2,5-cyclohexadien-1-one
2,5-Cyclohexadien-1-one, 4-[(E)-2-(1,3-benzodioxol-5-yl)-1-methylethenyl]-4,5-dimethoxy-2-(2-propen-1-yl)-
Futoquinol

Biological Activity

[Description]:

Futoquinol is a neolignan isolated from the dried aerial parts of Piper kadsura (Piperaceae). Futoquinol potently inhibits NO production in microglia cells. Futoquinol has anti-neuroinflammatory activities[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[In Vitro]

Futoquinol potently inhibits NO production with an IC50 value of 16.8 μM in LPS-activated BV-2 cells, a microglia cell line[1].

[References]

[1]. Ki Hyun Kim, et al. Neolignans from Piper kadsura and their anti-neuroinflammatory activity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):409-12.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
515.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₅

[ Molecular Weight ]:
354.396

[ Flash Point ]:
225.5±30.2 °C

[ Exact Mass ]:
354.146729

[ PSA ]:
53.99000

[ LogP ]:
4.82

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.582

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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