Adrenocorticotropic Hormone Fragment 1-10 human

Names

[ Name ]:
Adrenocorticotropic Hormone Fragment 1-10 human

[Synonym ]:
ADRENOCORTICOTROPIC HORMONE (1-14)
H.Ser.Tyr.Ser.Met.Glu.His.Phe.Arg.Trp.Gly.OH
SYSMEHFRWGKPVG
adrenocorticotropic hormone fragment 1-10
ACTH (1-14)
Adrenocorticotropic Hormone Fragment 1-10 human
SYSMEHFRWG
SYSMEHFRWG-OH
Adrenocorticotropic Hormone Fragment 1-10 human,rat
ADRENOCORTICOTROPIC HORMONE (1-10),HUMAN
SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY
ADRENOCORTICOTROPIC HORMONE (1-10)
Ser-Tyr-Ser-Met-Glu-His-<14C>Phe-Arg-Trp-Gly
Adrenocorticotropic Hormone (ACTH) (1-10), human

Biological Activity

[Description]:

Adrenocorticotropic Hormone (ACTH) (1-10), human, an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Metabolic Disease

[In Vitro]

α-melanocyte stimulating hormone (MSH) induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. Adrenocorticotropic hormone (ACTH) possesses the same amino acid sequence as MSH does[1].

[References]

[1]. Hirobe T, et al. ACTH(4-12) is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J Exp Zool. 2000 May 1;286(6):632-40.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Molecular Formula ]:
C₅₉H₇₈N₁₆O₁₆S

[ Molecular Weight ]:
1299.41000

[ Exact Mass ]:
1298.55000

[ PSA ]:
554.88000

[ LogP ]:
1.54880

[ Index of Refraction ]:
1.693

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ WGK Germany ]:
3.0

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Ligand-dependent activation of the melanocortin 5 receptor: cAMP production and ryanodine receptor-dependent elevations of [Ca(2+)](I).

Biochem. Biophys. Res. Commun. 290 , 844-850, (2002)

The melanocortins are involved in the regulation of various cognitive and physiological processes such as learning, feeding, immune suppression, pigmentation, and sebum production. Five melanocortin r...

Participation of ACTH1-10 and ACTH4-10 on the melatonin modulation of benzodiazepine receptors in rat cerebral cortex.

Experientia 51 , 209-212, (1995)

In this study, we examined the effect of intracerebroventricular (i.c.v) injection of melatonin and/or ACTH1-10 and ACTH4-10 on [3H]flunitrazepam binding sites in the cerebral cortex of hypophysectomi...

Molecular dynamics simulations of adrenocorticotropin (1-24) peptide in a solvated dodecylphosphocholine (DPC) micelle and in a dimyistoylphosphatidylcholine (DMPC) bilayer.

J. Biomol. Struct. Dyn. 20 , 39-57, (2002)

The structure and interactions of the 1-24 fragment of the adrenocorticotropin hormone, ACTH (1-24), with membrane have been studied by molecular dynamics (MD) simulation in an NPT ensembles in two ex...