Communic acid

Names

[ Name ]:
Communic acid

[Synonym ]:
(1S,4aR,5S,8aR)-1,4a-Dimethyl-6-methylene-5-[(2E)-3-methyl-2,4-pentadien-1-yl]decahydro-1-naphthalenecarboxylic acid
1-Naphthalenecarboxylic acid, decahydro-1,4a-dimethyl-6-methylene-5-[(2E)-3-methyl-2,4-pentadien-1-yl]-, (1S,4aR,5S,8aR)-

Biological Activity

[Description]:

Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC50 of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

15 μM (M. tuberculosis H37Ra) [2]

[References]

[1]. Samoylenko V, et al. Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. Phytother Res. 2008;22(12):1570-1576.

[2]. Carpenter CD, et al. Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis. J Ethnopharmacol. 2012;143(2):695-700.

[3]. Huh WB, et al. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K. PLoS One. 2015;10(6):e0128365. Published 2015 Jun 11.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
414.0±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₀O₂

[ Molecular Weight ]:
302.451

[ Flash Point ]:
199.8±20.3 °C

[ Exact Mass ]:
302.224579

[ PSA ]:
37.30000

[ LogP ]:
6.69

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.520

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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