Dual FAAH/sEH-IN-1

Names

[ Name ]:
Dual FAAH/sEH-IN-1

Biological Activity

[Description]:

Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual sEH (soluble epoxide hydrolase) and FAAH (fatty acid amide hydrolase) inhibitor, with IC50 values of 9.6 and 7 nM, respectively. Dual FAAH/sEH-IN-1 shows antinociception against the inflammatory phase[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH

Signaling Pathways >> Neuronal Signaling >> FAAH

[Target]

IC50: 9.6 nM (sEH) and 7 nM (FAAH)[1]

[References]

[1]. Wilt S, Kodani S, Valencia L, et al. Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorg Med Chem. 2021;51:116507.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₂ClN₃O₃S₂

[ Molecular Weight ]:
512.04

Related Compounds

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