H-Leu-Oet.HCl

Names

[ Name ]:
H-Leu-Oet.HCl

[Synonym ]:
dl-leucine ethyl ester hydrochloride
EINECS 220-375-6
(S)-Ethyl 2-amino-4-methylpentanoate hydrochloride
H-Leu-Oet.HCl
Ethyl L-isoleucinate hydrochloride (1:1)
EthylL-leucinatehydrochloride
H-Leu-OEt·HCl
L-Leucine Ethyl Ester Hydrochloride
L-Isoleucine, ethyl ester, hydrochloride (1:1)
MFCD00034879
leu-OEt HCl
L-LEUCINE ETHYL ESTER HCl
Ethyl 2-Amino-4-Methylpentanoate
ethyl 2-amino-4-methylpentanoate hydrochloride
L-leucine-OEt HCl

Biological Activity

[Description]:

H-Leu-OEt.HCl is a leucine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
0.944g/cm3

[ Boiling Point ]:
191.4ºC at 760 mmHg

[ Melting Point ]:
134-136 °C

[ Molecular Formula ]:
C₈H₁₈ClNO₂

[ Molecular Weight ]:
195.687

[ Flash Point ]:
62.9ºC

[ Exact Mass ]:
195.102600

[ PSA ]:
52.32000

[ LogP ]:
2.42520

[ Vapour Pressure ]:
0.515mmHg at 25°C

[ Index of Refraction ]:
19 ° (C=5, EtOH)

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Glutamate formation via the leucine-to-glutamate pathway of rat pancreas.

Am. J. Physiol. Gastrointest. Liver Physiol. 306(11) , G938-46, (2014)

The leucine-to-glutamate (Leu→Glu) pathway, which metabolizes the carbon atoms of l-leucine to form l-glutamate, was studied by incubation of rat tissue segments with l-[U-(14)C]leucine and estimation...

Synthesis of homopolypeptides by aminolysis mediated by proteases encapsulated in silica nanospheres.

Macromol. Biosci. 14(11) , 1619-26, (2014)

We report the encapsulation of three different proteases in bioinspired silica. Silica particles were formed under mild reaction conditions using cationic amine-rich ethyleneamines as initiators, whic...