Econazole

Names

[ Name ]:
Econazole

[Synonym ]:
1-{2-[(4-Chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
1-[2,4-Dichloro-b-[(p-chlorobenzyl)oxy]phenethyl]imidazole
1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
EINECS 248-341-6
Econazole
Ecostatin
Imidazole, 1-(2,4-dichloro-β-((p-chlorobenzyl)oxy)phenethyl)-
Gyno-Pevaryl
1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-
UNII:6Z1Y2V4A7M
Spectazole
Palavale
1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole
Epi-pevaryl
Ifenec
econazolum
Pevaryl
1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-
MFCD00800993

Biological Activity

[Description]:

Econazole is an antifungal compound of the imidazole class.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Infection

[References]

[1]. Thienpont D, et al. Bilogical and toxicological properties of econazole, a broad-spectrum antimycotic. Arzneimittelforschung. 1975 Feb;25(2):224-30.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
533.8±50.0 °C at 760 mmHg

[ Melting Point ]:
86.8ºC

[ Molecular Formula ]:
C₁₈H₁₅Cl₃N₂O

[ Molecular Weight ]:
381.684

[ Flash Point ]:
276.6±30.1 °C

[ Exact Mass ]:
380.024994

[ PSA ]:
27.05000

[ LogP ]:
5.32

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.615

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4767000

CHEMICAL NAME :: Imidazole, 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-

CAS REGISTRY NUMBER :: 27220-47-9

BEILSTEIN REFERENCE NO. :: 0964150

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H15-Cl3-N2-O

MOLECULAR WEIGHT :: 381.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,208,1989

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
24/25-36/37/39

Articles

The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules.

J. Chromatogr. A. 1218(43) , 7886-94, (2011)

This study describes using 0.1% of a 28-30% ammonium hydroxide solution as an additive to alcohol modifiers in SFC to improve chromatographic peak shapes for basic molecules. Ammonium hydroxide's high...

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.

Sci. Rep. 4 , 5285, (2014)

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular ...

Effect of methoxychlor on Ca(2+) movement and viability in MDCK renal tubular cells.

Basic Clin Pharmacol Toxicol. 111(4) , 224-31, (2012)

The effect of the insecticide methoxychlor on the physiology of renal tubular cells is unknown. This study aimed to explore the effect of methoxychlor on cytosolic Ca(2+) concentrations ([Ca(2+) ](i) ...