4,4'-diacetamidodiphenylmethane

Names

[ Name ]:
4,4'-diacetamidodiphenylmethane

[Synonym ]:
N,N'-AcetylMDA
4.4'-Bis-acetamino-diphenylmethan
N,N'-diacetyl-4,4'-methylenedianiline
4,4'-diacetoamino-diphenylmethane
N,N'-(Methylenedi-4,1-phenylene)diacetamide
4',4''-METHYLENEBIS(ACETANILIDE)
N1-{4-[4-(acetylamino)benzyl]phenyl}acetamide
4,4'-Diacetyldiaminodiphenylmethan
Acetamide, N,N'-(methylenedi-4,1-phenylene)bis-
N-[4-[(4-Acetamidophenyl)Methyl]Phenyl]Acetamide
BRD-K4477
FH1

Biological Activity

[Description]:

FH1(BRDK4477) is a small molecule that can enhance the functions of cultured hepatocytes.IC50 value:Target: In vitro: FH1(BRD-K4477) enhances hepatocyte functions, and promotes the maturation of well-differentiated cultures of iHeps, which potentially alleviates a major obstacle to the use of iPS cells as a renewable source of functional human hepatocytes.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[References]

[1]. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9(8):514-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
564.6±43.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₈N₂O₂

[ Molecular Weight ]:
282.337

[ Flash Point ]:
217.8±28.3 °C

[ Exact Mass ]:
282.136841

[ PSA ]:
58.20000

[ LogP ]:
1.93

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.635

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ Risk Phrases ]:
R22;R40

[ Safety Phrases ]:
S22-S36/37

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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