N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE

Names

[ Name ]:
N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE

[Synonym ]:
HMS3229O07
VEGF Receptor Tyrosine Kinase Inhibitor II

Biological Activity

[Description]:

VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit

[Target]

KDR:0.02 μM (IC50)

Flt-1:0.18 μM (IC50)

EGFR:0.24 μM (IC50)

[References]

[1]. Furet P, et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett. 2003;13(18):2967-2971.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆ClN₃O

[ Molecular Weight ]:
337.80300

[ Exact Mass ]:
337.09800

[ PSA ]:
54.02000

[ LogP ]:
4.74540

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.