(1S)-1,4-Anhydro-1-C-(2,4-difluorophenyl)-D-ribitol

Names

[ CAS No. ]:
263701-23-1

[ Name ]:
(1S)-1,4-Anhydro-1-C-(2,4-difluorophenyl)-D-ribitol

[Synonym ]:
1-deoxy-1-(2,4-difluorophenyl)--D-ribofuranose
21A41Y02XF
D-Ribitol, 1,4-anhydro-1-C-(2,4-difluorophenyl)-, (1S)-
(1S)-1,4-Anhydro-1-(2,4-difluorophenyl)-D-ribitol

Biological Activity

[Description]:

(1S)-1,4-Anhydro-1-C-(2,4-difluorophenyl)-D-ribitol is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
395.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H12F2O4

[ Molecular Weight ]:
246.21

[ Flash Point ]:
179.8±24.4 °C

[ Exact Mass ]:
246.070358

[ LogP ]:
1.14

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.567

Related Compounds

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