5-Methoxysalicylic Acid

Names

[ Name ]:
5-Methoxysalicylic Acid

[Synonym ]:
2-Hydroxy-5-methoxybenzoic acid
2-Hydroxy-5-methoxybenzadelhyde
MFCD00002459
5-Methoxy-2-hydroxybenzoic acid
5-methyloxysalicylic acid
m-Anisic acid,6-hydroxy
EINECS 220-037-8
6-hydroxy-m-Anisate
5-Methoxysalicylate
4-methoxysalicylic acid
Benzoic acid, 2-hydroxy-5-methoxy-
6-hydroxy-m-Anisic acid
Benzoic acid,2-hydroxy-5-methoxy
5-Methoxysalicylic Acid

Biological Activity

[Description]:

5-Methoxysalicylic acid (5-MeOSA) is a natural compound, used as a useful matrix in the MALDI MS analysis of oligonucleotides when combined with spermine[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Lee D, et al. 5-Methoxysalicylic acid matrix for ganglioside analysis with matrix-assisted laser desorption/ionization mass spectrometry. J Am Soc Mass Spectrom. 2015 Mar;26(3):522-5.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
347.0±27.0 °C at 760 mmHg

[ Melting Point ]:
141-143 °C(lit.)

[ Molecular Formula ]:
C₈H₈O₄

[ Molecular Weight ]:
168.147

[ Flash Point ]:
146.5±17.2 °C

[ Exact Mass ]:
168.042252

[ PSA ]:
66.76000

[ LogP ]:
2.10

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.586

[ Water Solubility ]:
1.7 g/L (10 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Profiling Aglycon-Recognizing Sites of UDP-glucose:glycoprotein Glucosyltransferase by Means of Squarate-Mediated Labeling.

Biochemistry 54 , 4909-17, (2015)

Because of its ability to selectively glucosylate misfolded glycoproteins, UDP-glucose:glycoprotein glucosyltransferase (UGGT) functions as a folding sensor in the glycoprotein quality control system ...

Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates.

Nat. Commun. 5 , 5170, (2014)

Sensitive detection of small molecule fragments binding to defined sites of biomacromolecules is still a considerable challenge. Here we demonstrate that protein-binding fragments are able to induce e...

Chemical characterization of milk oligosaccharides of the eastern quoll (Dasyurus viverrinus).

Glycoconj. J. 32 , 361-70, (2015)

Structural characterizations of marsupial milk oligosaccharides have been performed in four species to date: the tammar wallaby (Macropus eugenii), the red kangaroo (Macropus rufus), the koala (Phasco...