Mca-Pro-β-cyclohexyl-Ala-Gly-Nva-His-Ala-Dap(Dnp)-NH2 trifluoroacetate salt

Names

[ Name ]:
Mca-Pro-β-cyclohexyl-Ala-Gly-Nva-His-Ala-Dap(Dnp)-NH2 trifluoroacetate salt

Biological Activity

[Description]:

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-1

MMP-3

MMP-26

[References]

[1]. Park HI, et al. Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. J Biol Chem. 2002 Sep 20;277(38):35168-75.

[2]. Knäuper V, et al. The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity. Eur J Biochem. 2001 Mar;268(6):1888-96.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₁H₆₅N₁₃O₁₅

[ Molecular Weight ]:
1100.14000

[ Exact Mass ]:
1099.47000

[ PSA ]:
409.79000

[ LogP ]:
5.14830

Related Compounds

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