4-Nonylphenylboronic acid

Names

[ Name ]:
4-Nonylphenylboronic acid

[Synonym ]:
Boronic acid, B-(4-nonylphenyl)-
4-N-Nonylphenylboronic acid
4-N-NONYLBENZENEBORONIC ACID
MFCD02093070
(4-Nonylphenyl)boronic acid
4-Nonylphenylboronic acid

Biological Activity

[Description]:

FAAH/MAGL-IN-4 (Compound 13) is a potent fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) inhibitor with IC50s of 9.1 nM and 7.9 μM, respectively. FAAH/MAGL-IN-4 can be used for the research of pain and CNS disorders[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> FAAH

[Target]

IC50: 9.1 nM (FAAH), 7.9 μM (MAGL)[1]

[References]

[1]. Anna Minkkilä, et al. Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
385.3±35.0 °C at 760 mmHg

[ Melting Point ]:
82-85°C

[ Molecular Formula ]:
C₁₅H₂₅BO₂

[ Molecular Weight ]:
248.169

[ Flash Point ]:
186.8±25.9 °C

[ Exact Mass ]:
248.194763

[ PSA ]:
40.46000

[ LogP ]:
6.30

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.501

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

Related Compounds

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