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Hydroxy bosentan

Names

[ CAS No. ]:
253688-60-7

[ Name ]:
Hydroxy bosentan

[Synonym ]:
4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide
Hydroxy Bosentan
Ro 48-8634
Benzenesulfonamide,4-(2-hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]
Ro 48-5033
Bosentan Impurity 2

Biological Activity

[Description]:

Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

Human Endogenous Metabolite


[References]

[1]. Chen M, et al. Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazoleon the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentanin rats. Xenobiotica. 2019 Jul 3:1-8.

Chemical & Physical Properties

[ Density]:
1.372g/cm3

[ Boiling Point ]:
783.9ºC at 760 mmHg

[ Molecular Formula ]:
C27H29N5O7S

[ Molecular Weight ]:
567.61300

[ Flash Point ]:
427.9ºC

[ Exact Mass ]:
567.17900

[ PSA ]:
174.26000

[ LogP ]:
4.33010

[ Vapour Pressure ]:
7.01E-26mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds