KollicoatMAE 100 P

Names

[ Name ]:
KollicoatMAE 100 P

[Synonym ]:
Alcogum L 15
RM 4 (polymer)
Primal RM 4
Alcogum L 11
Eudragit L 30D55
Methacrylic acid copolymer dispersion,Methacrylic acid-ethyl acrylate copolymer
Acrysol RM 4
Rhoplex RM 4
Eudragit L 30D
Alcogum
Alcogum L 21

Chemical & Physical Properties

[ Boiling Point ]:
99.5ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₄O₄

[ Molecular Weight ]:
186.20500

[ Flash Point ]:
15.6ºC

[ Exact Mass ]:
186.08900

[ PSA ]:
63.60000

[ LogP ]:
1.38260

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OZ4395000

CHEMICAL NAME :: Methacrylic acid, polymer with ethyl acrylate

CAS REGISTRY NUMBER :: 25212-88-8

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 9 mg/plate

REFERENCE :: APHGAO Acta Pharmaceutica Hungarica. (Kultura, POB 149, H-1389 Budapest, Hungary) 1953- Adopts V.24 in 1955. Volume(issue)/page/year: 56,97,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9464 No. of Facilities: 4190 (estimated) No. of Industries: 46 No. of Occupations: 56 No. of Employees: 94790 (estimated) No. of Female Employees: 27628 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H332-H413

[ Precautionary Statements ]:
P261

[ RIDADR ]:
NONH for all modes of transport

Articles

pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat SR 30 D and the enteric polymer dispersion Kollicoat MAE 30 DP.

Eur. J. Pharm. Biopharm. 58 , 45-49, (2004)

The objective of this study was to obtain pH-independent release profiles from coated pellets containing drugs with pH-dependent solubility. pH-independent release of the basic model drug verapamil HC...

Evaluation of the drug release patterns and long term stability of aqueous and organic coated pellets by using blends of enteric and gastrointestinal insoluble polymers.

Int. J. Pharm. 380 , 112-119, (2009)

The major aim of this study was to identify an efficient tool to adjust drug release patterns from aqueous and organic ethylcellulose (a gastrointestinal insoluble polymer) coated pellets and to evalu...

Development of a novel osmotically driven drug delivery system for weakly basic drugs.

Eur. J. Pharm. Biopharm. 69 , 667-674, (2008)

The drug substance SAG/ZK has a short biological half-life and because of its weakly basic nature a strong pH-dependent solubility was observed. The aim of this study was to develop a controlled relea...

Related Compounds

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