SLV 320

Names

[ CAS No. ]:
251945-92-3

[ Name ]:
SLV 320

[Synonym ]:
UNII-O1Q96UZ63W
SLV 320
Derenofylline

Biological Activity

[Description]:

Derenofylline is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2Areceptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

Ki: 1 nM (adenosine A1 receptor)[1].

[References]

[1]. Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₀N₄O

[ Molecular Weight ]:
308.37800

[ Exact Mass ]:
308.16400

[ PSA ]:
73.83000

[ LogP ]:
3.41330

Related Compounds

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