Dexivacaine

Names

[ Name ]:
Dexivacaine

[Synonym ]:
Dexivacainum [INN-Latin]
(+)-Mepivacaine
Dexivacain
DEXIVACAINE
Dexivacaine [USAN:INN]
2',6'-Pipecoloxylidide,1-methyl-,L-(+)
(+)-1-Methyl-2',6'-pipecoloxylidide
(S)-Mepivacaine
Dexivacaina [INN-Spanish]
L(+)-Mepivacaine

Biological Activity

[Description]:

(+)-Mepivacaine is a racemic isomer of Mepivacaine (HY-B0517), which has analgesic and vasoconstrictive activity. Mepivacaine is an amide type agent that temporarily causes local loss of consciousness. Mepivacaine binds to specific voltage-gated sodium channels on neuronal cell membranes, inhibiting sodium influx and membrane depolarization[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Fairley J W, et al. An intradermal study of the local anaesthetic and vascular effects of the isomers of mepivacaine[J]. British Journal of Anaesthesia, 1981, 53(11): 1211-1216.

Chemical & Physical Properties

[ Density]:
1.077g/cm3

[ Boiling Point ]:
383.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₂₂N₂O

[ Molecular Weight ]:
246.35

[ Flash Point ]:
185.5ºC

[ Exact Mass ]:
246.17300

[ PSA ]:
35.83000

[ LogP ]:
3.31360

[ Vapour Pressure ]:
4.52E-06mmHg at 25°C

[ Index of Refraction ]:
1.567