1,2,7,8-Diepoxyoctane

Names

[ Name ]:
1,2,7,8-Diepoxyoctane

[Synonym ]:
octane-1,2,7,8-diepoxide
1,7-Octadiene Diepoxide
Octane,1,2:7,8-diepoxy
Oxirane, 2,2'-(1,4-butanediyl)bis-
2,2'-Butane-1,4-diyldioxirane
EINECS 219-375-9
MFCD00005155
2,2'-(1,4-Butanediyl)dioxirane
UNII:4IJ1M5W7LL
1,2-Epoxy-7,8-epoxyoctane
2-[4-(oxiran-2-yl)butyl]oxirane
Octa-1,7-diene diepoxide
1,2,7,8-Octadiene bisepoxide

Chemical & Physical Properties

[ Density]:
0.997

[ Boiling Point ]:
240.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₄O₂

[ Molecular Weight ]:
142.196

[ Flash Point ]:
98 ºC

[ Exact Mass ]:
142.099380

[ PSA ]:
25.06000

[ LogP ]:
0.86

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.445

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG9450000

CAS REGISTRY NUMBER :: 2426-07-5

BEILSTEIN REFERENCE NO. :: 0104873

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C8-H14-O2

MOLECULAR WEIGHT :: 142.22

WISWESSER LINE NOTATION :: T3OTJ B4- BT3OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1070 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 320 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6600 mg/kg/55W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 12500 nmol/L

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),587,1979

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H311-H341-H350

[ Precautionary Statements ]:
P201-P280-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R22;R24;R40

[ Safety Phrases ]:
S36/37/39-S45

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
RG9450000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2910900090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2910900090

[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress.

Genet. Mol. Res. 1(1) , 79-89, (2002)

The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substant...

Discrimination between genotoxicity and cytotoxicity for the induction of DNA double-strand breaks in cells treated with aldehydes and diepoxides.

Mutat. Res. 441(1) , 85-93, (1999)

The time-dependent dose-response relationships for the induction of DNA double-strand breaks (DSB) assessed by pulsed-field gel electrophoresis (PFGE) and for viability (evaluated by the MTT cytotoxic...

1,2,5,6-Diepoxyhexane and 1,2,7,8-diepoxyoctane cross-link duplex DNA at 5'-GNC sequences.

Chem. Res. Toxicol. 9(6) , 994-1000, (1996)

The carcinogenicity of epoxide compounds has been attributed to covalent binding to DNA. Whereas monoepoxides form only monoadducts, diepoxides can form both monoadducts and interstrand cross-links. T...

Related Compounds

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